![]() In a recent study, we found that age affected the clinical outcome in study participants with probable mild AD treated with deep brain stimulation targeting the fornix (DBS-f) as the experimental condition. Using data obtained from 10 studies and 2,793 probable AD participants, Schneider and colleagues reported that the younger participants had faster rates of cognitive decline than the older participants on the Alzheimer’s Disease Assessment Scale (ADAS-cog) over 12–24 months ( p < 0.0001). 1243-1257, 2021Īge of onset can be a confounding moderating variable in clinical trials of probable Alzheimer’s disease (AD) because many younger, early onset AD participants have a more rapid cognitive decline than later onset participants that may be associated with distinct genetic subtypes. Journal: Journal of Alzheimer's Disease, vol. Keywords: Age, Alzheimer’s disease, deep brain stimulation, clinical trials, subject selection Targum, 505 Tremont Street, #907, Boston MA 02116, USA. Penn Memory Center, Department of Neurology, University of Pennsylvania, Philadelphia, PA, USAĭepartments of and Neurosurgery and Neurology, University of Florida, Fixel Institute for Neurological Diseases, Gainesville, FL, USAĭepartment of Neurosurgery, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USAĬleveland Clinic Lou Ruvo Center for Brain Health, Cleveland, OH, USAĭepartment of Surgery (Neurosurgery), University of Toronto, Toronto, ON, CanadaĬorrespondence to: Steven D. Memory and Alzheimer’s Treatment Center & Alzheimer’s Disease Research Center, Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USAĭepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA bĪffiliations: Functional Neuromodulation Ltd., Minneapolis MN, USA a * | Fosdick, Lisa a | Drake, Kristen E.
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